How does prolotherapy differ from PRP therapy?

Prolotherapy uses a dextrose solution to trigger a healing response, while PRP uses concentrated growth factors from your own blood. Both stimulate repair at the cellular level. They can be combined for enhanced results — research shows PRP prolotherapy may offer even stronger tissue regeneration.

Is prolotherapy evidence-based?

Yes. Prolotherapy has decades of clinical research supporting its effectiveness for chronic musculoskeletal pain and joint instability, including randomized controlled trials.

Can I take pain medication during treatment?

Avoid anti-inflammatory medications (NSAIDs like ibuprofen) during your treatment series, as they suppress the inflammatory healing response that makes prolotherapy effective. Acetaminophen (Tylenol) is generally acceptable for managing discomfort.

Prolotherapy

Q: What conditions does prolotherapy treat?

Prolotherapy is used for ACL/MCL tears, arthritis, fibromyalgia, chronic headaches, back and neck pain, osteoarthritis, plantar fasciitis, sprains, tendonitis, tennis elbow, and many other musculoskeletal conditions involving weakened connective tissue.

Q: How many sessions will I need?

Most patients require 3–6 treatment sessions spaced 3–6 weeks apart, though some conditions respond after fewer treatments. Your plan is customized based on the severity and location of your condition.

Regenerative dextrose injections that strengthen damaged ligaments and tendons, restoring stability and relieving chronic pain — without surgery.

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What Is Prolotherapy?

Prolotherapy (proliferative therapy) is a time-tested regenerative injection treatment that stimulates your body to repair and strengthen weakened connective tissues. A natural dextrose (sugar water) solution is injected precisely at the attachment points of damaged ligaments, tendons, or joint capsules, triggering a controlled inflammatory response that activates your body’s healing cascade. The result is new collagen formation and stronger, more resilient connective tissue. At Glory Regenerative Center, Dr. Ikudayisi uses prolotherapy to treat a wide range of musculoskeletal conditions including ACL and MCL tears, arthritis, fibromyalgia, chronic headaches, back and neck pain, osteoarthritis, plantar fasciitis, sprains, tendonitis, and tennis elbow. Research supports that prolotherapy can be further enhanced when combined with PRP therapy, offering even more robust tissue regeneration.

Benefits

Strengthens weakened ligaments and tendons through natural collagen production
Reduces chronic joint instability and hypermobility
Treats pain in virtually any body region — neck, back, shoulders, elbows, wrists, hips, knees, ankles, and feet
Non-surgical alternative to joint replacement or ligament reconstruction
Decades of clinical evidence supporting long-term efficacy
Can treat multiple areas in a single session
Minimal downtime — most patients return to normal activities within days
Combines effectively with PRP for enhanced regeneration

Who Is a Good Candidate?

Prolotherapy is ideal for patients with chronic ligament or tendon laxity, joint instability, degenerative joint conditions, or musculoskeletal pain that hasn’t responded to physical therapy or conservative treatments. Conditions commonly treated include ACL/MCL tears, arthritis, fibromyalgia, chronic headaches, back pain, osteoarthritis, plantar fasciitis, sprains, tendonitis, and tennis elbow.

How It Works

Diagnostic Evaluation

Dr. Ikudayisi performs a thorough musculoskeletal exam, identifying the specific ligaments, tendons, or joints contributing to your pain and instability.

Solution Preparation

A medical-grade dextrose solution is prepared at the appropriate concentration for your condition and targeted anatomy.

Precise Injection

The solution is injected at the exact attachment points of damaged connective tissues, triggering your body’s natural inflammatory healing response.

Healing & Collagen Formation

Over 4–6 weeks, your body produces new collagen, gradually strengthening and stabilizing the treated tissues.

What to Expect

Each prolotherapy session takes approximately 30–45 minutes. You may experience mild discomfort during the injections and moderate soreness for 2–5 days afterward — this is a normal sign that the healing process has been activated. Most treatment plans include 3–6 sessions spaced 3–6 weeks apart, though some conditions respond after fewer treatments. Anti-inflammatory medications should be avoided during the healing window, as they can interfere with the regenerative process. Many patients notice meaningful improvement in pain, stability, and function after the second or third session.

Available At

Visit Us In Person

Tampa

8019 N. Himes Ave., Suite 200
Tampa, FL 33614

Mon–Tue 9am–3pm · Wed 9am–5pm · Thu–Fri 9am–3pm · Sat–Sun Closed

(813) 932-9798

Lakeland

1818 Harden Blvd., Suite 110
Lakeland, FL 33803

Mon & Wed–Fri 9am–3pm · Tue 9am–5pm · Sat–Sun Closed

(863) 248-6881

New Port Richey

5622 Marine Parkway, Suite 8
New Port Richey, FL 34652

Mon–Fri 9am–3pm · Sat–Sun Closed

(727) 232-0826

Frequently Asked Questions

Strengthen Your Foundation with Prolotherapy

Schedule a consultation to learn how dextrose-based regenerative injections can stabilize joints, repair connective tissue, and relieve chronic pain.

Book a Consultation Call (813) 932-9798